How UV Light Can Alter Microstructure of Human Skin: Study

“Leathery” complexions are often hallmarks of having spent too much time in the sun—whether in the real deal or the tanning booth. Binghamton University researchers have looked more closely at this issue. Their study, published in the Journal of the Mechanical Behavior of Biomedical Materials, explores how ultraviolet radiation can alter the microstructure of human skin. According to the team, particularly affected is collagen, the fibrous protein that binds together tissue, tendon, cartilage and bone throughout our bodies.

Binghamton University Associate Professor of Biomedical Engineering Guy German headed the research at the Thomas J. Watson College of Engineering and Applied Science’s Department of Biomedical Engineering. His team included PhD student Abraham Ittycheri, Zachary Lipsky, PhD ’21, and Assistant Professor Tracy Hookway.

The study’s title is: “Ultraviolet light induces mechanical and structural changes in full thickness human skin.”

The new study builds on previous research from German and Lipsky that focused on the outer stratum corneum, which is the top layer of skin. This time, the Binghamton team compared full-thickness skin samples before and after various levels of UV exposure.

“One way to characterize the material characteristics of skin is by conducting a mechanical stretch test on it,” Ittycheri said. “If it stretches very easily, it’s relatively compliant, but if it’s much harder to stretch it, you can characterize it as much stiffer. My experiment was to see what the isolated effects of UV light would be and compare it with a scenario where a skin is not exposed to UV light.”

The researchers found that as the skin absorbed more UV radiation, the collagen fibers in it became more tightly packed together, leading to increased stiffness and tissue that is harder to break. German sees correlations with the cross‐linkage theory of aging, which proposes that the accumulation of undesirable molecular bonds over time can cause cellular dysfunction.

Hookway — winner of a National Science Foundation CAREER Award earlier this year for her research on cardiac cells — sees similarities between how heart and skin cells deal with damage, even though they have very different functions.

“Our body has this natural response in any tissue when there’s some sort of injury, which likely happens in the stratum corneum,” she said. “First, wherever there’s some sort of weakening, there has to be compensation by some other part of the tissue or else there’ll be catastrophic failure. Same thing happens in the heart when you have a myocardial infarction — you build up a scar and your heart’s going to not work the same way anymore.”

Sometimes, she added, the body’s reaction will keep you alive but isn’t necessarily a good result, possibly leading to other medical issues later. Figuring out the mechanics of how it all happens could allow future doctors to steer the reactions in a healthier direction.

Following this research, further collaborations among Ittycheri, German and Hookway are already in the works. The skin is the body’s largest organ and the first line of protection against microbes and other outside attacks, so ways to maintain and even strengthen it are clearly beneficial.

“Any kind of disruption to the normal process of skin is going to be extremely dangerous and detrimental to our overall lifestyle,” Ittycheri said. “That’s not even going into the cosmetic side of things, where a person’s perception about themselves can be challenged when their skin does not look good.”